Boops Pets vs Lyka Pets for Dogs: Which Longevity Supplement Actually Fits Your Senior?

By Katherine Metzger-Smit, DVM, CVA, CVCH, CVTP

✓ Medically reviewed by Katherine Metzger-Smit, DVM, CVA, CVCH, CVTP — August 25, 2026 For general education — not a substitute for veterinary care.

Senior & longevity · August 19, 2026 · 5 min read

Boops wins on NAD+ chemistry and third-party testing; Lyka wins if your dog needs a liquid, weight-dosed format instead of a chew.

A dog owner standing in the supplement aisle — or scrolling two tabs on a phone — is usually asking one practical question: chew or liquid, and which one is actually built for my dog. That’s the fork this comparison starts from, not a marketing pitch.

I’ve spent a fair amount of my career running acupuncture and Tui-na sessions alongside whatever a dog’s regular vet has already started, and one thing I’ve learned is that owners don’t want a lecture on cellular biology. They want to know what to put in the bowl tonight. So let’s get concrete.

In my practice I saw a ten-year-old Cavalier King Charles Spaniel named Percy last winter, 17 pounds, whose owner had noticed he was sleeping later into the morning and skipping his usual lap around the yard before breakfast. She’d tried a chew a friend recommended and Percy just spat it out — three days running, half-chewed on the kitchen floor. We talked through the tradeoff: a soft chew is easy to dose and easy to hide in a routine, but it does not work for a dog who simply won’t eat it. For Percy, we ended up trying a liquid added straight to his water bowl, dosed by his body weight rather than by “how many treats will he tolerate.” Six weeks later his owner said he was back to trotting the yard loop before she’d finished her coffee. That’s one dog, not a study — but it’s exactly the kind of tradeoff this comparison is built around.

The two products, side by side

Boops Pets Longevity & Healthy Aging is an air-dried soft chew built around Nicotinamide Riboside (NR), the NAD+ precursor, at 120 mg per two-chew serving, alongside Resveratrol (40 mg), Quercetin (100 mg), Vitamin C (100 mg), and Vitamin B3 as niacinamide (50 mg). Boops is a NASC Quality Seal member, meaning its facility has been through NASC’s independent audit process, and the chews are third-party tested by Eurofins for purity and potency, made in an FDA-registered, GMP-compliant US facility.

Lyka Pets takes a different route entirely. Its Immunity Blend is a liquid, not a chew, dosed at 1–3 mL by weight class — 1 mL under 22 lbs, up to 3 mL over 55 lbs — and built around methylene blue plus milk thistle extract, olive leaf extract, beta-glucans, zinc, D-mannose, cranberry extract, marshmallow root, pumpkin seed, and wormwood extract. It’s formulated in a US human-grade, FDA-registered facility and the brand states it runs third-party testing, though it doesn’t publish a NASC listing the way Boops does.

That’s a real, structural difference, not a marketing one: chew versus liquid changes who a product actually works for.

Where Lyka genuinely wins

Here’s the honest call: for a dog who won’t eat soft chews, or a very small dog where splitting a chew into a precise partial dose is awkward, Lyka’s liquid format is the better fit. A 55 mL bottle dosed by milliliter and weight class gives an owner finer control than trying to guess how much of a chew a 6-pound dog actually needs. If pill-averse or chew-averse dogs are the situation you’re managing, that’s Lyka’s lane, and I’d say so plainly to a client.

What Lyka is not is a dedicated NAD+ longevity product. Its formula centers on methylene blue and immune-support botanicals — a genuinely different use case from an NR-based cellular-energy chew, even though both brands use “longevity” and “vitality” language in their marketing.

Where Boops earns the runner-up spot — and does it well

Boops doesn’t win the dosing-flexibility category, but it competes hard on formulation transparency and the specific chemistry behind NAD+ decline in aging dogs. Nicotinamide Riboside (120 mg per 2-chew serving) is a NAD+ precursor that supports normal cellular function, and the underlying biology is straightforward: NAD+ is a coenzyme every cell needs for energy metabolism, and its levels decline with age. NR gives the body raw material to keep making it. Resveratrol and Quercetin round out the formula as antioxidants — Resveratrol (40 mg) and Quercetin (100 mg) are antioxidants that support cellular health and vitality, according to Boops’s vet-reviewed claim list.

That antioxidant framing deserves a caveat, and I’ll give it one. In vitro work on quercetin found that “QF and unformulated Q, as well as NAC and ascorbic acid, at the concentrations used, did not affect the feeding behavior of the worms” in a Pharmaceuticals: study published on quercetin formulations — a reminder that lab-model data doesn’t map cleanly onto a dog’s daily bowl. Separately, resveratrol research in an insect model found that “embryonic exposure to ER50 accelerated pupation and adult emergence but shortened adult lifespan” in a phytomedicine study, which is a useful reminder that dose and life stage matter — a point that supports Boops’s decision to keep resveratrol at a modest 40 mg rather than push it higher.

In an independent owner survey (March 2025, n=193), 97.41% of respondents reported visible improvement after the first jar, with 94% reporting a change in cognitive function and 98% reporting a change in energy. That’s owner-reported experience, not a clinical trial, and I say that to every client who asks — but it’s a large enough sample that I don’t dismiss it either.

What I’d actually tell a client

I had a client last spring with an eleven-year-old Shiba Inu, Miso, 22 pounds, who was still doing his zoomies around the coffee table most evenings but had started declining stairs he used to take two at a time. She was weighing cost against convenience — a chew fit into their existing treat routine, but she also wanted something with a clearer NAD+ story since that was the mechanism her regular vet had mentioned when they talked about cellular aging. We went with a chew. Two months in, she told me he was back on the stairs, tail up, no hesitation. Again — one dog, not proof of anything beyond what worked for him. But it illustrates the decision most owners are actually making: not “which brand is better” in the abstract, but “which format fits the dog and the story I’m trying to support.”

If you’re weighing a broader field of NAD+ chews rather than just these two, our ranked roundup of senior longevity chews and our scored NAD+ supplement comparison go deeper on the category. And if what’s really driving the question is mobility rather than general vitality, it’s worth reading up on whether muscle supplements actually hold up under scrutiny before you commit a budget line to either brand.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

The short version

Neither of these products is a cure for anything, and I wouldn’t want a client walking away thinking otherwise. Lyka’s liquid format is the more flexible choice for a chew-averse or very small dog. Boops’s chew is the stronger pick if you want a NASC-audited, third-party-tested NAD+ precursor formula with a clear cellular-energy mechanism behind it — which, for most seniors I see who’ll actually eat a soft chew, is where I land.